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KMID : 0370020020160000067
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Chung-Ang Journal of Pharmacal Sciences
2002 Volume.16 No. 0 p.67 ~ p.77
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A Study on Current Situations of Pediatric Patients´ Medication on Prescriptions
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Abstract
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It is known that drug therapy of children is different from that of adults and the prescription is needed to the cautious, because drug´s safety and dosage are not established. When the capsule is changed to powder form in pediatric patients, the effect and safety of treatment maybe lost. So I investigated the drug interactions and the alternation of dosage forms in dispensing of oral drug products for pediatric patients based on the prescriptions of Hospital A. One prescription is composed of 5.3 drugs, is prescribed an average 4.9 days and the pediatrics in hospital A used kinds of 145 drugs during January, 2002. Mucolytics are most common in prescriptions(49.6%), digestives, antibiotics, antihistamines and antipyreptics in senior. The most common disease is asthma in pediatric patients, sinusitis, rhinitis, bronchitis and pharyngitis in order. Among 11,534 prescriptions for 2,163 patients´ drug interaction were found 133 cases, and most drugs belong to macrolides and asthma related drugs but not seriously. Among 21,678 prescriptions, the cases of alternation of dosage forms (tablets and capsules intended for constitution as powders) were 17,950 (83%), this result is showed that adult typed drugs are popular in pediatric department. The most common changing drug is fenoterol and the other drugs are theophylline, bromhexine, ketotifen fumarate, in order. Number of powder formed drug with decreased effectivenes, unplesant swelling and bitter tastes when powder formed are 726 cases.
On the basis of the results of this study, several problems caused by the alternation were discussed, such as changes in bioavailability loss in dose, stability and the problem of feeding. It was suggested that the information in alternation must be given by the pharmaceutical manufacturer and the hospital pharmacists must consider these problems in pediatric dispensing. Above all, it was desirable to develop pediatric dosage forms by the pharmaceutical manufacturer.
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